- Metabolic biomarkers
- Heart and vascular diseases
- Diabetes
- Obesity
- Metabolic liver disease (NASH/MASH)
- Imprinting disorders
Discover our scientific projects that need your support
Your support is essential to fight cardiometabolic diseases (obesity, diabetes, cardiovascular diseases, liver diseases, etc.). Thanks to donations and patronage, the IHU ICAN teams of physicians and researchers accelerate innovation for the benefit of patients.
This list is a non-exhaustive selection of the many IHU ICAN projects.
Click on a project to learn more about its context, objectives, and the stakeholders involved.
Metabolic biomarkers
ICONIC : 1st cardiac and hepatic imaging atlas in the general population
Meditwin : using digital twins to diagnose cardiovascular disease risk for high-risk patients
Heart and vascular diseases
ACORE : Diagnostic and prognostic contribution, and pathophysiological aspects in arrhythmogenic cardiomyopathy
AROME : This project aims to explore the role of the CASK protein in the context of two cardiac arrhythmias: atrial fibrillation and arrhythmogenic cardiomyopathy
Duration: 3 years Budget: €395,000
CARE : Study of the characteristics and impact of treating cardiac rhythm disorders with catheter ablation
CALORR : Better understanding splicing alterations responsible for cardiomyopathies thanks to third-generation sequencing
CAVD : using artificial cardiac pseudo-tissues (EHT) for new approaches to treating Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
CT-AF : Automated quantification of left atrial subepicardial fat on CT and atrial strain on MRI: contribution to atrial fibrillation ablation
GEN-RAR : Searching for rare genetic etiologies in patients with dilated cardiomyopathies or rhythm disorders
MAESTRIA : the first digital platform for integrative diagnosis of atrial cardiomyopathy, using artificial intelligence
PEGASE : Heart transplantation after a prolonged preservation period using an ex vivo perfusion device
SICD-PSL : Observatory of Subcutaneous Implantable Defibrillators at Pitié Salpêtrière
UTHOPIA/ROBEDUC : Artificial Intelligence (AI) to raise awareness for therapeutic education and telemedicine
Diabetes
MET-INF-T2D : Metabolic inflexibility of the heart as a predictor of the onset of heart failure in patients with type 2 diabetes
Design and evaluation of a predictive biomarker for the risk of diabetic foot ulceration
Obesity
Study of the protective mechanisms of omega-3 fatty acids in obesity
Ob-Mat : maternal obesity and developmental myocardial abnormalities leading to heart failure
Metabolic liver disease (MASH, MASLD)
CARSTEL : Hepatic carcinogenesis and metabolic steatopathies: mechanisms, epidemiological burden, clinical phenotyping, and individual risk stratification
EDC-MASLD : better understanding the progression of MASLD to severe forms, notably the role of environmental exposures
LIVERAIM : improving early detection of chronic liver diseases by developing a new personalized risk calculator based on biomarkers
MAS-HCC-PREDICT : better understanding the factors that influence survival and treatment response in patients with hepatocellular carcinoma (HCC), particularly those related to MASLD
Imprinting disorders
Epigenetics : induced pluripotent stem cells, a promising cellular model to study imprinting disorders
