ICAN Omics lipidomics
What is lipidomics?
Lipids are small molecules that are insoluble or sparingly soluble in water. Lipids play an essential role in all biological species. Lipidomics is the science of lipid composition in biological samples. Lipidomic alterations are observed in human tissues and fluids in pathological conditions, including cardiometabolic diseases such as cardiovascular disorders, diabetes and obesity. Lipidomics combines state-of-the-art technologies to provide a holistic view of these perturbations, molecular details of altered biochemical pathways and biomarkers for therapeutic use.
ICAN Omics lipidomics platform
Cutting-edge technologies such as mass spectrometry coupled with gas or liquid chromatography enable IHU ICAN to guarantee ultra-sensitive, quantitative analyses of hundreds of lipid species in various biological matrices.
Expertise and services
“On the ICAN Omics lipidomics platform at IHU ICAN, 450 lipid species are routinely measured, including > 230 glycerophospholipids, 70 sphingolipids and > 130 neutral lipids. These studies have led to dozens of publications in international peer-reviewed journals and several patent applications involving new disease biomarkers.”
Dr Anatol Kontush, Directeur scientifique (UMR ICAN 1166).
Equipment on the platform
- GC-MS: Trace 1310/ISQ LT (ThermoFisherScientific)
- LC-MS/MS: HPLC (Prominence Shimadzu)/ QTrap 4000 (AB Sciex)
- UPLC-HRMS Acquity Wtaers/ QExactive (ThermoFisherScientific)
- Pre-analytical automaton LV200 (Biotage)
- Precellys Evolution homogenizer (Ozyme),
- Positive pressure manifold (Waters positive pressure manifold – 96)
- SPD131DDA speed vacuum concentrator with cryogenic trap (Thermo Fisher Scientific)
Current developments
- Sphingosines, sphingosine-1-phosphate
- Oxysterols
- Long-chain acylcarnitines
Certificates
IBiSA label obtained in 2020. Learn more.
Team
Dr Anatol Kontush (DR, UMR ICAN 1166)
Scientific Director
Marie Lhomme (IR, ICAN)
Operational manager
Laura Desnouveaux
Research engineer ICAN Omics
Nitharsshini Nirmalathasan
Assistant engineer ICAN Omics
Network
Scientific Committee
Dr G. I. Boneca (Pasteur)
Dr F. Fenaille (CEA)
Dr. F. Lamari (APHP)
Wilfried Le Goff (UMR ICAN 1166)
Prof. F. Mochel (ICM)
Contact
Marie Lhomme
01 84 82 77 67
47-48 hospital bd
75013 Paris
ICAN – building E3M – 6th floor
Access conditions
- Download the form below and return to m.lhomme@ihuican.org
- Your project will be submitted to the steering committee
- After validation, estimate drawn up and project initiated
Major Publications
