ICAN BioCollection

The Biological Resource Center (BRC) ICAN BioCollection

The CRB ICAN BioCollection (formerly named Bio ICAN) integrates activities of collection/reception, sample processing (centrifugation, aliquoting, DNA and RNA extraction, …), storage at -20°C, -80°C and -150°C with temperature monitoring and provision of biological resources. Several types of biological samples are stored in ICAN BioCollection: serum, plasma, buffy coat, adipose tissue (subcutaneous, mesenteric, omental), liver tissue, urine, stool, saliva… New sample treatments can be set up at the user’s request.

Team

The CRB team is made up of its manager Sara CIPRIANI, PhD, as well as the technical team, with Jean-Baptiste BLOND, Ludivine HARMAND, and Houdah ALI KASSIM. The quality manager of the CRB is Abdelhafid ATTAR, quality engineer.

The governance of the CRB is ensured by an Executive Committee (COMEX)

Discover the CRB ICAN BioCollection Organization Chart

Certificate

The CRB ICAN BioCollection obtained the double certification ISO 9001 : 2015 and NF S 96-900 : 2011 in December 2019 for the reception, preparation, conservation, provision of biological resources of human origin relating to cardiometabolic diseases and the hosting of biological samples. This certification was granted by the Euro-quality system certification body in November 2019. This is the result of a quality approach initiated many years ago and testifies to the willingness of CRB ICAN BioCollection to continuously improve the quality of its services in order to guarantee the satisfaction of its stakeholders.

Certification ISO 90012015
Certification NF S 96900201

Benefits

Direct debit management

  • Preparation of sampling kits
  • Receipt of direct debits
  • Sample management: serum, plasma, PBMC, circulating and cellular DNA and RNA extraction, urine
  • Stool aliquoting
  • Non-invasive labeling of samples (use of QR-code tube)
  • Inventory

Storage of biological samples

  • Storage temperature variable according to needs: – 20°C, – 80°C, -150°C
  • Temperature tracking report
  • Collection duplication (two levels of separation between two freezers; separation between two storage sites)
  • Storage capacity: 1 million samples
  • 24/7 temperature monitoring; on-call weekends and public holidays

Return of biological samples

  • Preparation of samples for shipment
  • Transport organization

Support for these services is provided by the expertise of Sara CIPRIANI. In addition, the IHU ICAN offers many other services with its technical platforms, clinical platform, etc. You can see them here .

Political quality

The quality policy is a requirement of the NF S96-900:2011 and ISO 9001: 2015 standard. It presents the orientations in terms of quality given by the management in connection with the strategy of the IHU ICAN. It is the reference allowing to direct the quality approach.

La politique Qualité est consultable ici : Quality Policy – CRB ICAN BioCollection

Quality Manual

Our Quality Manual is a document describing the Quality Management System (QMS) of our CRB. It defines the organization of our structure meeting the scope of the dual certification NF S96-900 and ISO 9001, describes the processes and establishes the list of our procedures.

Terms of cooperation

Within the framework of its collaborations, the BRC has drafted a Charter which aims to govern the relationship between ICAN BioCollection and its Interested Parties in accordance with the ethical principles governing the collection of elements and products of the human body as well as their derivatives, and with the legislative and regulatory provisions governing the activity of collection, processing and storage of the said products, as well as the information associated with them.

In order to optimize the use of the Collections and the samples currently deposited and to be deposited in the future, ICAN BioCollection has drafted this policy, the terms of which will be binding on all persons accessing ICAN BioCollection services.

La Charte Bio-ICAN est consultable ici : Charte CRB ICAN BioCollection
Reproduction and use without permission prohibited.

Support for these services is provided by the expertise of Sara CIPRIANI. In addition, the IHU ICAN offers many other services with its technical platforms, clinical platform, etc. You can see them here .

Legal authorization

  1. The bank declared its activity to the Ministry in charge of Research under the number DC – 2013 – 1971, dated 26/07/2014
  2. The bank has declared compliance with MR004 (2204190 v 0).

Key figures

26

Scientific cohorts

24

Phase II and III clinical studies

1500+

Direct debits received each year

7000+

Samples prepared each year

6000+

Samples made available each year

Collectible catalog

In this table you will find the available biological sample collections.

If you are interested in our Biological Resources, or for the establishment of a collection of Biological Resources within the CRB, you can contact the CRB by CRB.Bio-ICAN@ihuican.org or fill out our request forms below.

collection

Approach

pathology

Acute Coronary Syndrome

sample(s)

Serum, plasma, DNA, urine, stool

Responsible

Prof. Johanne SILVAIN

started in

2015

Summary

Acute Coronary Syndrome (ACS) is the obstruction of one or more coronary arteries. The objective of this study is to better understand the etiology and pathophysiology of acute coronary syndrome. The APPROACH collection was created in 2015 by Pr. Johanne SILVAIN PU-PH within the Cardiology Department of the Pitié Salpêtrière – Charles Foix University Hospitals, and is made up of serum, plasma, urine, stool and DNA samples with numerous associated clinical data.

collection

Myocardium

pathology

Heart failure / cardiomyopathy

sample(s)

Serum, plasma, DNA, urine, stool

Responsible

Prof. Richard ISNARD

started in

2015

Summary

The purpose of this study is to monitor patients suffering from heart failure syndrome or cardiomyopathy (CMD). The syndrome is heterogeneous and one of the objectives of this project is to highlight or validate new diagnostic and prognostic biomarkers. The MYOCARD collection was created in 2015 by Pr. Philippe Charron PU-PH within the Cardiology Department of the Pitié Salpêtrière – Charles Foix University Hospitals, and is made up of serum, plasma, urine, stool and DNA samples with numerous associated clinical data.

collection

iPS-CARDIOGEN

pathology

Hereditary Heart Diseases (cardiomyopathies/electrical diseases)/hereditary vascular diseases

sample(s)

Serum, DNA, PBMC, Skin fibroblasts

Responsible

Prof. Philippe CHARRON

started in

2015

Summary

The mechanisms related to human hereditary heart or vascular diseases remain largely unknown. The objective of the iPS-CARDIOGEN study is to develop new experimental models to study hereditary heart and vascular diseases. The iPS-CARDIOGEN collection was created in 2015 by Pr. Philippe Charron, PU-PH within the Reference Center for Cardiac Diseases of the Pitié Salpêtrière – Charles Foix University Hospitals, and is made up of serum and DNA samples with numerous associated clinical data. Link to relevant study:
http://www.cardiogen.aphp.fr/upload/presentation_ips_cardiogen.pdf​

collection

FIFA/EPOS/LITMUS

pathology

Metabolic steatosis of the liver

sample(s)

Blood, plasma, urine, liver biopsy

Responsible

Prof. Vlad RATZIU

started in

2015

Summary

Metabolic fatty liver is a chronic liver disease associated with the presence of one or more metabolic risk factors or sleep apnea syndrome, in the absence of another cause of chronic liver disease. Metabolic steatosis can progress to liver fibrosis and cirrhosis. The main research axes of the study related to the collection are the understanding of the physiopathology of metabolic steatosis of the liver and the development of diagnostic tools. The FIFA-EPOS collection was created in 2015 by Pr. Vlad Ratziu, PU-PH in the Hepato-gastro-enterology department of the Pitié Salpêtrière – Charles Foix University Hospitals, and consists of serum and DNA samples with numerous associated clinical data. Link to relevant study:
http://www.epos-nafld.eu/
https://cordis.europa.eu/project/rcn/193284/factsheet/en
https://litmus-project.eu/
https://cordis.europa.eu/project/id/777377/fr

collection

FH-CALC

pathology

Heterozygous autosomal dominant familial hypercholesterolemia

sample(s)

Serum, Plasma, stool

Responsible

dr. Antonio Gallo

started in

2018

Summary

Familial hypercholesterolemia is an inherited metabolic disorder characterized by elevated LDL cholesterol in the blood. The main lines of research of the FH-CALC study are the understanding of the pathophysiology of familial hypercholesterolemia and the development of diagnostic tools. The FH-CALC collection was created in 2018 by Dr. Antonio Gallo, Associate Practitioner, Internist at the Cardiovascular Disease Prevention Unit of the Cardiology and Metabolism Center of the Pitié Salpêtrière – Charles Foix University Hospitals and is made up of serum, plasma and stool samples. Numerous clinical data are associated with the samples.

collection

CORO NASH

pathology

Metabolic fatty liver/cardiovascular disease

sample(s)

DNA, serum, stool, liver biopsy

Responsible

dr. Raluca Pais

started in

2018

Summary

The relationship between metabolic fatty liver disease (NAFLD), metabolic steatohepatitis of the liver (NASH) and atherosclerotic coronary artery disease (MC-ATS) is now recognized due to common cardiometabolic risk factors (FRMs), the likely role of NAFLD/NASH in the occurrence of pre-atherosclerotic lesions and myocardial dysfunction associated with NAFLD/NASH. The aim of this study is to determine the prevalence of NAFLD/NASH in patients admitted to cardiology with suspected coronary disease. The CORO-NASH collection was created in 2019 by Dr. Raluca Pais within the Hepato-Gastroenterology Department of the Pitié Salpêtrière – Charles Foix University Hospitals, and is made up of DNA, serum, stool, liver biopsy samples with numerous associated clinical data.

collection

Obeco

pathology

Obesity

sample(s)

Serum

Responsible

Prof. Anne Bachelot

started in

2018

Summary

The effectiveness of oral contraceptives depends on blood levels of these drugs after digestive absorption and their distribution in the body. Surgeries for obesity with malabsorption (gastric bypass) can in theory alter the biological availability of drugs in obese patients. The aim of this study is to evaluate the pharmacokinetics of oral contraceptives in obese women before and after bariatric surgery. The OBECO collection was created in 2015 by Pr. Anne Bachelot, Pu-PH in the Endocrinology and Reproductive Medicine Department of the Pitié Salpêtrière – Charles Foix University Hospitals, and is made up of serum samples with numerous clinical data associated with the samples.

collection

CARDIO-MET

pathology

Familial hypercholesterolemia

sample(s)

Serum, plasma

Responsible

Professor Eric BRUCKERT

started in

2021

Summary

The crucial role of dyslipidemia, particularly hypercholesterolemia, in the development of cardiovascular disease is particularly well documented. Familial hypercholesterolemia (FH) is a genetic disease characterized by elevated plasma concentrations of LDLC. Lipoproteins rich in triglycerides (TRL), contribute to the progression of cardiovascular diseases. The aim of this study is to compare the apolipoproteic profile of patients with HF by comparing those with associated hyperTG with those with isolated hypercholesterolemia. The CARDIO-MET collection was created in 2021 by Pr Eric BRUCKERT within the Endocrinology and Metabolism Department of the Pitié Salpêtrière – Charles Foix University Hospitals, and consists of serum and plasma samples with associated clinical data.

collection

IMPULSMACS

pathology

Heart failure

sample(s)

Serum, DNA, circulating RNA, PBMC

Responsible

Dr Guillaume Lebreton

started in

2021

Summary

The implantation of LVAD (Left Ventricular Assist Device) constitutes a medium to long-term therapeutic option for patients with end-stage heart failure with isolated left ventricular dysfunction. However, their use remains limited by the frequency of their side effects, which are mostly unpredictable. Several factors, including pulsatility, have been associated with LVAD complications in the literature, including bleeding complications. However, the pathophysiological pathways associated with decreased pulsatility are poorly understood. The prospective follow-up of the patients included in this study aims to study the pathophysiological pathways associated with the reduction in pulsatility and leading to complications of LVAD. The IMPULSMACS collection was created in 2021 by Dr Guillaume Lebreton in the Cardiac Surgery Department of the Pitié Salpêtrière University Hospitals – Charles Foix, and consists of samples of serum, DNA, circulating RNA, PBMC with associated clinical data. Link to relevant study: https://clinicaltrials.gov/ct2/show/NCT04951999

Pricing of services

benefits

ICAN/SU (€/unit)

Academic (excluding SU) & Industrial

Receipt of sample tubes

Reception

7 €

CRI grid

Freezing (without technicage)

Tube

€1

CRI grid

Technicage

Preparation serum/plasma 2D tube

€2.30

CRI grid

Serum/plasma preparation 2ml tube

€2.30

CRI grid

Stool aliquoting

€2.50

CRI grid

Tissue preparation for inclusion

€2.50

CRI grid

DNA extraction from blood

33 €

CRI grid

RNA extraction from soft tissue (except adipose tissue)

35 €

CRI grid

Plasma/serum RNA extraction

28 €

CRI grid

Size adipocytes

18 €

CRI grid

Technician HR time excluding technicage (€/h)

28 €

CRI grid

Step freezing

8 €

CRI grid

PBMC Preparation

30 €

CRI grid

Cell count and viability

7 €

CRI grid

Freezing viable cells

9 €

CRI grid

Storage

2D tube -80°C

€0.05

CRI grid

Tube 2ml -80°C

€0.08

CRI grid

Tube 5ml -80°C

€0.34

CRI grid

Tube 12ml-15ml -80°C

€0.60

CRI grid

Tube 2ml – 150°C

€1.05

CRI grid

Destocking

Tube

€1

CRI grid

Click here to consult the national price list for CRBs and certified hospital tumor banks​ established by the Research and Innovation Commission (CRI) of the Conference of General Managers of CHU.

Contact(s)

Sara CIPRIANI

Operational manager

Building E3M – 6th floor
47-48 hospital bd
75013 Paris ICAN

You wish…

Set up a collection?

Fill in the form

Make an exit request for biological resources?

Fill in the form

Feedback via our satisfaction questionnaire?

Fill in the form

Processing of your personal data: The processing complies with the provisions of the CNIL (law relating to data processing, files and freedoms as well as the general regulations on data protection). To exercise your rights regarding the processing of your personal data: mesdonnees@ican-institute.org

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