ICAN Omics lipidomics
What is lipidomics?
- Lipids are small molecules that are insoluble or sparingly soluble in water. Lipids play an essential role in all biological species.
- Lipidomics is the science of lipid composition in biological samples. Lipidomic alterations are observed in human tissues and fluids in pathological conditions, including cardiometabolic diseases such as cardiovascular disorders, diabetes and obesity.
- Lipidomics combines state-of-the-art technologies to provide a holistic view of these perturbations, molecular details of altered biochemical pathways and biomarkers for therapeutic use.
ICAN Omics lipidomics platform
Cutting-edge technologies such as mass spectrometry coupled with gas or liquid chromatography enable IHU ICAN to guarantee ultra-sensitive, quantitative analyses of hundreds of lipid species in various biological matrices.
Our expertise
On the ICAN Omics lipidomics platform at IHU ICAN, 450 lipid species are routinely measured, including >, 70 sphingolipids and > These studies have led to dozens of publications in international peer-reviewed journals and several patent applications involving new disease biomarkers.”
Dr Anatol Kontush, Directeur scientifique (UMR ICAN 1166).
Download the list of our molecules
Current developments
- Long-chain acylcarnitines
- Oxysterols
- Negative-mode phospholipids with fatty acid elucidation in sn1 and sn2
Equipment
- GC-MS: Trace 1310/ISQ LT (ThermoFisherScientific)
- LC-MS/MS: HPLC (Prominence Shimadzu)/ QTrap 4000 (AB Sciex)
- UPLC-HRMS Acquity Wtaers/ QExactive (ThermoFisherScientific)
- Pre-analytical automaton LV200 (Biotage)
- Precellys Evolution homogenizer (Ozyme),
- Positive pressure manifold (Waters positive pressure manifold – 96)
- SPD131DDA speed vacuum concentrator with cryogenic trap (Thermo Fisher Scientific)
Certificates
IBiSA label renewed in 2023. Learn more.
Steering Committee
Dr Anatol Kontush (DR, UMR ICAN 1166)Scientific DirectorMarie Lhomme (IR, ICAN)Operational manager
Scientific Committee
- Dr F. Fenaille (CEA)
- Dr. I. Gomperts Boneca (Institut Pasteur)
- Dr F. Lamari (APHP)
- Wilfried Le Goff (UMR ICAN 1166)
- Pr F. Mochel (ICM)
Network
Access conditions
- Download the form below and e-mail it to m.lhomme@ihuican.org.
- Your project will be submitted to the steering committee.
- Once approved, a quotation will be drawn up to initiate the project.
Download the formDownload the user charter
Contact
Marie Lhommem.lhomme@ihuican.org01 84 82 77 67
47-48 hospital bd
75013 Paris
ICAN – building E3M – 6th floor
Major Publications
Latest publications12/03/2024Perturbation and resilience of the gut microbiome up to 3 months after β-lactams exposure in healthy volunteers suggest an important role of microbial β-lactamases15/12/2023Acute myocardial infarction preferentially alters low-abundant, long-chain unsaturated phospholipid and sphingolipid species in plasma high-density lipoprotein subpopulations17/10/2023Fluid shear stress triggers cholesterol biosynthesis and uptake in inner medullary collecting duct cells, independently of nephrocystin-1 and nephrocystin-401/10/2023Deleterious functional consequences of perfluoroalkyl substances accumulation into the myelin sheath01/09/2023Impaired metabolism predicts coronary artery calcification in women with systemic lupus erythematosus23/08/2023Identification of the specific molecular and functional signatures of pre-beta-HDL: relevance to cardiovascular disease27/07/2023Integrated omics approach for the identification of HDL structure-function relationships in PCSK9-related familial hypercholesterolemia28/03/2023Lipidomic analysis of adipose-derived extracellular vesicles reveals specific EV lipid sorting informative of the obesity metabolic state09/12/2022Impacts of a high-fat diet on the metabolic profile and the phenotype of atrial myocardium in mice19/05/2022Plasma FA composition in familial LCAT deficiency indicates SOAT2-derived cholesteryl ester formation in humans13/04/2022Phosphatidylserine enhances anti-inflammatory effects of reconstituted HDL in macrophages via distinct intracellular pathwaysOlder publications28/10/2020Inclusion of endophenotypes in a standard GWAS facilitates a detailed mechanistic understanding of genetic elements that control blood lipid levels13/08/2020Loss of G protein pathway suppressor 2 in human adipocytes triggers lipid remodeling by upregulating ATP binding cassette subfamily G member 110/01/2020Exploring the Bacterial Impact on Cholesterol Cycle: A Numerical Study27/11/2019The intestinal microbiota regulates host cholesterol homeostasis11/10/2019Elevated serum ceramides are linked with obesity-associated gut dysbiosis and impaired glucose metabolism10/03/2017Serum lipidomics reveals early differential effects of gastric bypass compared with banding on phospholipids and sphingolipids independent of differences in weight loss21/01/2016D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile08/11/2014Circulating phospholipid profiling identifies portal contribution to NASH signature in obesity01/11/2013Unraveling the complexities of the HDL lipidome03/10/2013Small, dense high-density lipoprotein-3 particles are enriched in negatively charged phospholipids: relevance to cellular cholesterol efflux, antioxidative, antithrombotic, anti-inflammatory, and antiapoptotic functionalitiesDiscover ICAN Omics metabolomicsI make a donation to support research
