In 2025, the IHU ICAN organized a Scientific Day dedicated to cardiometabolic diseases for its scientific community, within the Faculty of Sciences of Sorbonne University, with the support of GIRCI Île-De-France and the participation of NovoNordisk and Boehringer Ingelheim.
This event brought together researchers, clinicians, and external experts to discuss recent advances in the fields of metabolic and cardiovascular diseases, providing the ideal conditions for promoting knowledge exchange and inspiring young researchers.
A program dedicated to cardiometabolism
The day began with opening speeches by Professor Stéphane Hatem (Director General of IHU ICAN) and Anne-Marie Armanteras (Chair of the Board of Directors), who emphasized the importance of collaborative research and innovation in the medical field.
The opening lecture, presented by Jean-Sébastien Silvestre, Director of the Paris Cardiovascular Research Center (PARCC), focused on research in “Cardio-immunology: at the heart of immunity.” This session highlighted the complex interactions between the immune system and cardiovascular diseases.
The first session of oral presentations, dedicated to research on metabolic diseases and moderated by Jérémie Gautheron and Dr. Chloé Amouyal, presented cutting-edge research. Among the speakers, Dr. Tatiana Lecot-Conan shared her findings on the use of machine learning and metabolomics to identify metabolic signatures of polycystic ovary syndrome. Other presentations covered a variety of topics, such as age-related metabolic disorders and mitochondrial dysfunction, illustrating the diversity and depth of research in this field.
The second session, focused on clinical research in cardiology, was moderated by Nadjia Kachenoura and Prof. Estelle Gandjbakhch. Participants learned about innovative studies, such as the computational fluid dynamics analysis of blood flow in the left atrium in patients with atrial fibrillation, presented by Louis Parker. This session also included a presentation on findings in periungual capillaroscopy in patients suspected of having microvascular angina, highlighting recent clinical advances.
The afternoon featured a scientific poster presentation session, offering young researchers the opportunity to present their work and exchange ideas with experts. This interactive session provided an opportunity to discover promising research and encouraged discussion and collaboration among participants.
The third session of oral presentations, focused on fundamental and translational research in cardiology and moderated by Laurent Kappeler and Marie Lagouge, presented advanced research work. Among the presentations, Laetitia Rialland shared her research on splicing variants in hypertrophic cardiomyopathies. The presentations illustrated the importance of translational research in bridging the gap between fundamental discoveries and clinical applications.
The day ended with a lecture on microvascular endothelial cells in adipose tissue, presented by Anne Bouloumié from the Institute of Metabolic and Cardiovascular Diseases in Toulouse.
An awards ceremony followed, recognizing the best oral presentations and posters by young researchers.
Discover the winners’ projects
The jury awarded prizes to four research projects (two best oral presentations and two best scientific posters) based on a set of predefined criteria (impact of the project, appeal, clarity, relevance, originality, scientific quality, quality of the oral presentation, responses to questions, etc.). Congratulations to the winners!
Best Oral Presentations
Jury: Marie LAGOUGE (PhD), Véronique BEREZIAT (PhD), Dr. Wilfried LE GOFF
• “Targeted mRNA sequencing and refined bioinformatics pipeline as an innovative way to reclassify splicing variants in Hypertrophic Cardiomyopathies and improve diagnostic yield,“ Laetitia Rialland, Genomics and Pathophysiology of Cardiovascular Diseases, UMRS_1166-ICAN, Cardiovascular and Metabolic Diseases
• “Computational Fluid Dynamics Analysis of Left Atrial Blood Flow in Patients with Atrial Fibrillation,” Louis Parker, Cardiovascular Imaging – LIB Biomedical Imaging Laboratory Inserm U1146 CNRS UMR 7371
Best scientific posters
Jury: Dr. Michel ZEITOUNI, Dr. Maryse GUÉRIN, Prof. Bruno FÈVE
• “The role of hepatocyte mitochondrial dysfunction in the onset and progression of MASLD,” Sonny Yde (UMRS_1166-ICAN, Cardiovascular and Metabolic Diseases, Pasteur Institute)
• “Nailfold Capillaroscopic Findings in Patients With Suspected Microvascular Angina,” Omar EL ZOUHAYRI (Atherothrombosis and Applied Pharmacology, UMRS_1166-ICAN, Cardiovascular and Metabolic Diseases)
Discover the research topics presented
Session 1: Research in Metabolic Diseases
- Combining machine learning and metabolomics to identify the metabolic signatures of polycystic ovary syndrome patients according to body mass index, Tatiana LECOT-CONAN (Endocrinology and Reproductive Medicine, Pitié-Salpêtrière Hospital, APHP)
- Unraveling the Impact of Adipose-Glucocorticoid Signaling on Age-Related Metabolic Disorders, Carine BEAUPÈRE (Lipodystrophies, Metabolic and Hormonal Adaptations, and Aging, UMRS_938, Saint-Antoine Research Center (CRSA)
- Adipocyte-specific Mlkl knockout mitigates obesity-induced metabolic dysfunction by enhancing mitochondrial functions, Juliette TOKGOZOGLU (Metabolic and Biliary Fibro-inflammatory Liver Diseases, UMRS_938, Saint-Antoine Research Center (CRSA)
- Contribution of adipocyte ABCG1 expression to obesity and associated metabolic disorders, Canelle REYDELLET (Cellular and Systemic Lipid Metabolism in Cardiometabolic Diseases, UMRS_1166-ICAN, Cardiovascular and Metabolic Diseases)
- Effects of GLP-1 receptor agonists on insulin resistance, dyslipidemia, and hepatic steatosis in patients with familial partial lipodystrophy, Camille VATIER (Lipodystrophies, Metabolic & Hormonal Adaptations, and Aging, UMRS_938, Saint-Antoine Research Center (CRSA), Endocrinology, Diabetology, and Reproductive Endocrinology, Saint-Antoine Hospital, APHP)
- Liver-heart crosstalk: the role of hepatic S1P in metabolic heart disease development, Franck PHAN (Metabolic Diseases, Diabetes, and Comorbidities, UMRS_1166-ICAN, Cardiovascular and Metabolic Diseases, Department: Diabetology, Pitié-Salpêtrière Hospital, APHP)
Session 2: Clinical Cardiovascular Research
- Phenotyping heterogeneity of recurrent myocarditis in the AMPHIBIA registry, Mathieu PROUST (Department: Cardiology, Pitié-Salpêtrière)
- Nailfold Capillaroscopic Findings in Patients with Suspected Microvascular Angina, Niki PROCOPI (Atherothrombosis and Applied Pharmacology, UMRS_1166-ICAN, Cardiovascular and Metabolic Diseases, Department: Cardiology, Pitié-Salpêtrière Hospital)
- Computational Fluid Dynamics Analysis of Left Atrial Blood Flow in Patients with Atrial Fibrillation, Louis PARKER (Cardiovascular Imaging – LIB Biomedical Imaging Laboratory Inserm U1146 CNRS UMR 7371)
- AI-Driven Multimodal Insights in Atrial Cardiomyopathy, Maharajah PONNAIAH (ICAN I/O – Data Science)
Session 3: Fundamental & Translational Cardiovascular Research
- Targeted mRNA sequencing and refined bioinformatics pipeline as an innovative way to reclassify splicing variants in Hypertrophic Cardiomyopathies and improve diagnostic yield, Laetitia Rialland (Genomics and Pathophysiology of Cardiovascular Diseases, UMRS_1166-ICAN, Cardiovascular and Metabolic Diseases)
- Distinct role of macrophages in atrial cardiomyopathy associated with obesity, Nadine SUFFEE (Molecular and Cellular Plasticity in Cardiovascular Diseases, UMRS_1166-ICAN, Cardiovascular and Metabolic Diseases)
- Cardiometabolic trajectories in familial hypercholesterolemia, Prof. Antonio GALLO (Unit of Lipidology and Cardiovascular Prevention, Competence Center for Rare Dyslipidemias (CEDRA), Department of Nutrition, Pitié-Salpêtrière Hospital, APHP)
Presentations by invited external experts
- Clinical development in cardiometabolism, Dr. Isabelle Lonjon-Domanec (VP CMR, Novo Nordisk France—Sponsor)
- Updates on Boehringer Ingelheim pipeline, Delphine BOUSQUET (National Lead for Scientific Experts, Boehringer Ingelheim – Sponsor)
- Cardio-Immunology: At the Heart of Immunity Jean-Sébastien SILVESTRE (Director, Paris Cardiovascular Research Center (PARCC)
- Microvascular Endothelial Cells in Adipose Tissue: Exploring their heterogeneity and functional diversity, Anne BOULOUMIÉ (Institute of Metabolic and Cardiovascular Diseases, Inserm UMR 1297 – University of Toulouse)
Thanks to all those involved
The ICAN IHU would like to thank everyone involved in making this edition a success, and in particular its partners NovoNordisk and Boehringer Ingelheim, the GIRCI Île-De-France for its invaluable support, and the Faculty of Sciences at Sorbonne University.
Save the date: Science Day 2026!
Are you a member of the IHU ICAN research community? Mark the date in your calendar now: the next IHU ICAN Science Day will take place on Thursday, April 9, 2026!
For any questions: communication@ihuican.org
