Scientists progress

1 - Inverse association between the richness of the microbiota and obesity and metabolic disorders (Cotillard 2013)

The depletion of the intestinal microbial flora promotes obesity and metabolic diseases such as diabetes.

2 - Discovery of a new mutation on an ion channel in pulmonary arterial hypertension (NEJM 2013)

Discovery of a gene coding for an ion channel whose mutation is responsible for the familial form of pulmonary arterial hypertension, a severe disease.

3 - Circulating phospholipids as a signature of NASH in obese people (J. Hepat 2015)

The depletion of the intestinal microbial flora promotes obesity and metabolic diseases such as diabetes.

4 - Causal link established between epicardial adipose tissue and atrial fibrillation (Venteclef EHJ 2015)

Discovery of a gene coding for an ion channel whose mutation is responsible for the familial form of pulmonary arterial hypertension, a severe disease.

5 - Stair-use interventions in worksites and public settings (Bellicha Prev Med 2015)

Program for maintaining physical activity using means accessible on a daily basis in the workplace, such as the use of stairs

6 - Development of an in vitro model to test antifibrotic drugs on primary human liver myofibroblasts (Aoudjehane Lab Invest 2016)

Development of an ex vivo human liver model that allows testing the efficacy of new drugs aimed at reducing liver disease

7 - Identification of a new cardiac protein that allows electrical conduction in the longitudinal direction of cardiac fibers (Eichel Circ Res 2016)

8 - 1st worldwide clinic (MC4R Obesity treatment) (Clement Nat Med 2018) 2017 Study launch

Medical treatment of a rare form of obesity of genetic origin

9 - 1st model of brown adipocytes derived from iPS cells (Guenantin Diabetes 2017)

Development of an in vitro model to test the effectiveness of new anti-obesity drugs.

10 - Launch of an action plan on clinical cohorts (2017)

This Cohorts plan has led to the establishment of numerous partnerships and large-scale research projects.

11 - ECMO (2017)

Description and study of the impact on patients with severe cardio-circulatory failure of extracorporeal oxygenation techniques (ECMO) used in intensive care units.

12 - The deformation of the atria wall correlates with the presence of fibro-adipose infiltrations in the heart (Hubert Radiology 2018)

Development of imaging software that allows clinical study of fatty tissue content and cardiac muscle fibrosis.

17 - Launch of the CALYPSO project (2018)

Development of new turbines used in the development of new artificial heart type systems.

18 - Association of steatosis with pre-atherosclerotic lesions by measuring the coronary calcium score in cohorts of patients at cardiovascular risk (Pais Hepatology 2019)

Description of a dialogue between the liver and the arteries which promotes the formation of atherosclerotic plaques.

15 - Identification of a lipid compound involved in insulin resistance in patients with metabolic syndrome (Bandet Foufelle Bourron Diabetes 2018)

16 - Reference article on a familial form of rhythmic heart disease, an important cause of sudden death in young patients (Gandjbakhch JACC 2018)

13 - 1st European Cardiomyopathy Registry (Charron EHJ 2018)

Establishment of a new register of the different types of familial cardiomyopathies and which allows standardized medical care in Europe.

14 - Cholesterol Efflux capacity is independently associated with survival in myocardial infarction patients (Guerin, Silvain JACC 2018)

Description of a new biomarker of severity and risk of complications after myocardial infarction.

21 - Mobilization of IHU teams on COVID-19 (2020)

The IHU teams mobilized from the first wave allowing the implementation of diagnostic tools to identify patients at high risk of severe forms of COVID requiring transfer to intensive care.

22 - Identification of a new receptor involved in the death of liver cells in liver diseases by lipid overload (Maajdi J Hepat 2020)

19 - DLK1 (2019)

Description of an epigenetic type process affecting a DLK1 gene involved in pathologies by parental imprint, Silver-Russel syndrome.

20 - 1st Patient in Cardiovascular Research MRI (2020)

Opening of the first platform dedicated to cardiovascular imaging research in Ile-de-France.

23 - Publication of new European recommendations for the care of patients with familial dyslipidemia (Bruckert Eur Heart 2020)

Funding by Europe of the first project to set up a digital platform to improve the identification of patients at risk of atrial fibrillation and stroke.