ICAN Omics metabolomics
What is metabolomics?
- Metabolomics is the exhaustive study of all small organic molecules (less than 1000 Da). Metabolites and associated biochemical reactions form a common basis for the proper functioning of all organisms, with some specific features in certain cases.
- To achieve this, it is possible to analyze the metabolites contained in biological matrices (plasma, serum, tissues, feces, etc.) in order to search for deregulations, compared to a control population for example.
- The metabolism is based on a delicate balance: it constantly responds to recurrent external stimuli such as food, or to more specific stimuli such as the onset of a pathology.
- The ultimate aim is to detect and quantify these metabolites that are outside the norm, in order to improve the prevention and/or treatment of various pathologies (better stratification of patients for more personalized treatment, adaptation of their lifestyle…).
The ICAN Omics metabolomics platform
- The expertise of the ICAN Omics metabolomics platform is to propose different approaches to help develop precision medicine: with a simple blood test and a signature including various specific metabolites, it is possible to improve the prevention and/or treatment of various pathologies.
- Our approaches are based on the profiling of a large number of metabolites using multidisciplinary skills combining bioinformatics, statistical tools and biochemical databases for the interpretation of results using a high-resolution mass spectrometer coupled to chromatographic systems.
- Our approaches are adapted to the search for candidate biomarkers for diagnostic, prognostic and treatment response purposes.
- Other so-called targeted (or profiling) approaches rely on published or known markers to verify and/or validate their relevance to a pathology, or to represent a specific signature of a population.
Our expertise
- Metabolome study
- Acquisition and interpretation of metabolomic profiles
- Analysis and quantification of several families of metabolites
- Advice and implementation of metabolomic assays
- Annotation, identification and structural elucidation of metabolites (HRMS, MS/MS)
- Development and realization of specific methods (‘Custom method’)
Targeted approach
- Absolute quantification of amino acids, tryptophan pathway, choline metabolism pathway (TMAO, Choline…), short chain fatty acids (SCFAs), bile acids (in dvlpt)
Untargeted approach
- Study of the global metabolome using several chromatographic methods
- Detection of more than 200 metabolites in biofluids (plasma-serum)
Profiling method
Detection and relative quantification of microbiota-related compounds belonging to the
- Method 1: amino acids, organic compounds, phenols, methylamines and some indoles
- Method 2: Acylcarnitines, free fatty acids and bile acids
Biological study matrices
- Serum-Plasma, CSF, urine, faeces, Cecum, PBMC and glial cells.
- Other matrices under pilot study conditions
Contact the operational manager for more information – Farid Ichou f.ichou@ihuican.org
Steering Committee
Philippe Lesnik, (DR, UMR ICAN 1166)
Scientific Director
Farid Ichou (IR, ICAN)
Operational manager
Scientific Committee
- Dr G. I. Boneca (Pasteur)
- Dr F. Fenaille (CEA)
- Dr. I. Gomperts Boneca (Institut Pasteur)
- Dr F. Lamari (APHP)
- Wilfried Le Goff (UMR ICAN 1166)
- Pr F. Mochel (ICM)
Network
- Training: reference platform for the Biomics course of the STA2E master’s degree from Université Paris Est Créteil
- Local networks: UMS RésOmique (Sorbonne University), AP-HP, Inserm U1166
- National networks: MetaboHub, RFMF, INSERM Microbiota Consortium
- International networks: Metabomeeting, european regional metabolomics networks, Metabolomics Society
Access conditions
Access to our platform is via an analytical request.
The procedure after receipt of the request form is as follows:
- Submission of the request form to the platform via “ Analytical request ” to the platform manager Farid Ichou: f.ichou@ihuican.org
- Project evaluation and establishment of a tariff proposal
- Validation of the specifications and signature of an estimate/agreement
- Receipt of samples
- Execution of the works according to the specifications (or the estimate)
- Presentation of the final study report
Contact
Farid Ichou (IR, ICAN)
01 84 82 77 68
47-48 hospital bd
75013 Paris
ICAN – building E3M – 6th floor
Major Publications
Latest publications
12/03/2024
01/02/2024
01/10/2023
29/09/2023
09/12/2022
12/08/2022
08/03/2022
02/06/2021
Older publications
19/11/2020
10/01/2020
01/01/2020
06/12/2019
01/09/2019
05/02/2019
29/01/2019
14/01/2019
27/11/2018
08/02/2018
13/01/2018
