ICAN Omics metabolomics: metabolite profiling platform

Objectives of the ICAN Omics metabolomics platform

The strategy developed within our ICAN Omics metabolomics platform is based on the following principles profiling of a wide range of metabolites using multi-disciplinary skills that combine bioinformatics, statistics and biochemical databases for interpretation of results using a high-resolution mass spectrometer coupled to chromatographic systems.

Services and Equipment

Metabolome study
Acquisition and interpretation of metabolomic profiles
Analysis and quantification of several families of metabolites
Advice and implementation of metabolomic assays
Annotation, identification and structural elucidation of metabolites (HRMS, MS/MS)
Development and realization of specific methods (‘Custom method’)

Targeted approach

Quantification absolue des acides aminés, voie du tryptophane, voie du métabolisme de la choline (TMAO, Choline…), acide gras à courte chaine (SCFAs), acides biliaires (en dvlpt)

Untargeted approach

Study of the global metabolome using several chromatographic methods
Detection of more than 200 metabolites in biofluids (plasma-serum)

Profiling method

Detection and relative quantification of microbiota-related compounds belonging to the

Method 1: amino acids, organic compounds, phenols, methylamines and some indoles
Method 2: Acylcarnitines, free fatty acids and bile acids

Biological study matrices

Sérum-Plasma, LCR, urines, fèces, Caecum, PBMC et cellules gliales.
Autres matrices sous conditions d’études pilotes

Contacter le responsable opérationnel pour plus d’informations – Farid Ichou f.ichou@ihuican.org

Networks and Collaborations

Training: reference platform for the Biomics course of the STA2E master’s degree from Université Paris Est Créteil
Local networks: UMS RésOmique (Sorbonne University), AP-HP, Inserm U1166
National networks: MetaboHub, RFMF, INSERM Microbiota Consortium
International networks: Metabomeeting, european regional metabolomics networks, Metabolomics Society

Access conditions

Access to our platform is via an analytical request.

The procedure after receipt of the request form is as follows:

Submission of the request form to the platform via “ Analytical request ” to the platform manager Farid Ichou: f.ichou@ihuican.org
Project evaluation and establishment of a tariff proposal
Validation of the specifications and signature of an estimate/agreement
Receipt of samples
Execution of the works according to the specifications (or the estimate)
Presentation of the final study report