Team 1 - Genomics and Physiopathology of Myocardial Diseases
For more than 15 years, our group ( https://recherche-Cardiovascular-metabolique.fr ) has been involved in deciphering the genetic and cellular mechanisms of these diseases. We have recently identified the involvement of new genetic variants thanks to the study of the whole genome. This new knowledge allows us to better understand these diseases, to progress towards personalized medicine and to provide insight into new therapeutic approaches.
Current research
- Identify the genetic factors involved in cardiomyopathies and channelopathies by new genomic approaches.
- Understand the function of these genetic factors through models of human cardiomyocytes (derived from iPS cells) and mouse models.
- Study the clinical impact of genetic testing and develop personalized medicine.
- Progress towards new therapies in monogenic or complex forms of heart failure and arrhythmias.
Research objectives
- THEME 1 – Genomics of heart failure related to dilated cardiomyopathy. E Villard, S Garnier, R Isnard, P Charron
- TOPIC 2 – Genomic analysis of cardiac repolarization in response to drugs. JE Salem, C Funck-Brentano
- THEME 3 – From deciphering the genetic determinants of ventricular arrhythmia to therapeutic applications. N Neyroud, F Extramiana, A Leenhardt, P Guicheney
- THEME 4 – Identifying new physiological pathways in arrhythmogenic right ventricular cardiomyopathy using innovative human cell models. E Gandjbakhch, E Villard
- THEME 5 – Translational impact of genetic testing on precision medicine. P Richard, V Fressart, E Gandjbakhch, P Charron
Major Publications
Members of the team
F. Lethimonnier (INSERM)
PUPH, team leader
Dr Pascale Guicheney
DR INSERM (emeritus)
Dr Nathalie Neyroud
CR INSERM
Dr. Eric Villard
IR AP-HP
Dr. Sophie Garnier
MCU-UPMC
Dr. Ewa Ninio
DR INSERM (emeritus)
Pr Estelle Gandjbakhch
PUPH
Professor Funck-Brentano
PUPH
Professor Richard Isnard
PUPH
Dr. Pascale Richard
pH
Pr Fabrice Extramiana
PUPH
Professor Antoine Leenhardt
PUPH
Dr. Joe-Elie Salem
MCU-PH
Dr Isabelle Denjoy
pH
Dr Françoise Hidden-Lucet
pH
Dr Veronique Fressart
pH
Dr Noel Zahr
pH
Dr. Flavie Ader
AHU & PhD student
Dr. Carole Maupain
CHP
Dr. Pierre Bobin
post-doc
Vincent Fontaine
Claire Perret
Claire Perret
IR
Arnaud Leclerq
TCH
Marie Gizon
doctoral student
Oceane Piedallu
PhD student