Carine Beaupère
Ph.D., Bruno Fève’s “Lipodystrophies, metabolic and hormonal adaptations, and aging” team at the CRSA
Awards / Distinctions
- 2022 Société Francophone du Diabète research grant – Lilly
- 2020 Association aide aux jeunes diabétiques research grant
Training
As a former student at Pierre et Marie Curie University, I specialized in the study of ageing from the Master’s level onwards.
I did my PhD at the Saint-Antoine research center (CRSA) under the supervision of Jacqueline Capeau and Claire Lagathu, with the aim of understanding the mechanisms involved in bone ageing in HIV-infected patients.
I then moved to Boston in the USA for a 4-year post-doctorate to study the regulation of longevity in the yeast model using multi-omics approaches.
I then came back to the CRSA, in Bruno Fève’s team, to do a second postdoctorate and then to be recruited as an INSERM researcher (CRCN) in 2023. My main theme is the study of aging, particularly metabolic aging. Aging is associated with an increased risk of developing various diseases, such as cancer, neurodegeneration and cardiometabolic pathologies.
By understanding the mechanisms of aging, we can develop strategies to delay it and thus avoid the emergence of these pathologies. It’s a very exciting prospect, and one that has fascinated me since I was a student.
Research is a passionate profession that offers a great deal of thematic freedom, there’s very little routine. It’s also a very competitive, international environment, which I find very stimulating.
Research project
I’m interested in the mechanisms involved in metabolic aging. In particular, a class of steroid hormones, glucocorticoids, are known to regulate glucidoprotein metabolism, but also inflammation.
Aging is accompanied by metabolic and pro-inflammatory deregulations that lead to various pathologies such as diabetes, cardiovascular disease, lipodystrophy and bone demineralization. The role of glucocorticoids makes them ideal targets for the study of aging , especially as endogenous glucocorticoid production is altered with age, and overexposure to glucocorticoids predisposes to metabolic diseases, lipodystrophy, muscle wasting and bone demineralization.
My research project therefore proposes to clarify the impact of glucocorticoids on body and adipose tissue aging, insulin sensitivity and cellular senescence. This study will demonstrate that the glucocorticoid receptor, particularly in adipocytes, is an interesting therapeutic target for preventing age-related cardio-metabolic disorders and increasing healthy life expectancy.
In parallel, I’m studying the impact of aging on glucocorticoid sensitivity. Synthetic glucocorticoids, such as cortisone, are often prescribed for their strong anti-inflammatory and immunosuppressive effects, particularly in patients over 65. For proper patient management, it is therefore important to know the impact of age on the response to corticosteroids.
“The glucocorticoid receptor, particularly in adipocytes, is an interesting therapeutic target for preventing age-related cardio-metabolic disorders and increasing healthy life expectancy”.
Publications
- Patnaik PK, Beaupere CBarlit H, Romero AM, Tsuchiya M, Muir M, Martínez-Pastor MT, Puig S, Kaeberlein M, Labunskyy VM, Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function. (2022) Cell Reports, Jul 19;40(3):111113
- Beaupere, CDinatto, L., Wasko, B.M., Chen, R.B., VanValkenburg, L., Kiflezghi, M.G., Lee, M.B., Promislow, D.E.L., Dang, W., Kaeberlein, M., Labunskyy, V.M. Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast (2018) Proceedings of the National Academy of Sciences of the United States of America, 115 (38), pp. 9586-9591
- Beaupere, C., Wasko, B.M., Lorusso, J., Kennedy, B.K., Kaeberlein, M., Labunskyy, V.M. CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes (2017) Cell Reports, 18 (8), pp. 1884-1892.
