The CARE project: study of the characteristics and impact of treating cardiac arrhythmias by catheter ablation
Background
- Heart rhythm disorders are on the rise in Europe due to the prevalence of cardiovascular disease.
- Atrial fibrillation (AF) is a common heart rhythm disorder and the most frequent type of atrial arrhythmia. It is responsible for nearly 20% of ischemic strokes (blockage of the carotid artery).
- Ventricular arrhythmias, such as ventricular tachycardia (VT) and ventricular fibrillation (VF), are associated with significant morbidity and mortality, particularly sudden death.
- Catheter ablation is currently the most widely used treatment for this condition. The rhythmology unit at La Pitié-Salpêtrière Hospital is a pioneer in this treatment strategy and treats the most complex arrhythmias.
- However, the targets for treatment to eliminate arrhythmia foci remain controversial, with a fairly heterogeneous approach depending on the electrophysiology team.
To address the heterogeneity of approaches, it is now necessary to characterize these complex arrhythmias more precisely during catheter ablation, as well as the long-term benefits and risks of this treatment, in order to improve our impact on the control of rhythm disorders.
Project objectives
- Evaluate the benefits and risks associated with ablation treatment for cardiac arrhythmias.
- The project also includes numerous secondary objectives (follow-up evaluations, predictive criteria for success, assessment of complications, description of characteristics, determination of imaging parameters, etc.).
Patient benefits
Improving the management of complex cardiac arrhythmias
Duration of the study
- Total duration of the study: 10 years (8-year inclusion period + 2-year follow-up)
- Retrospective data period: 2012–2020
Overall budget
€1,177,269
Project leaders
Dr. Nicolas BADENCO (Cardiology Institute – Rhythmology Unit, IHU ICAN (Cardiometabolism and Nutrition), INSERM 1166, APHP Sorbonne University – Pitié Salpêtrière Hospital)
Prof. Estelle GANDJBAKHCH (Cardiology Institute – Rhythmology Unit, IHU ICAN (Cardiometabolism and Nutrition), INSERM 1166, Reference Center for Hereditary Heart Disease, APHP Sorbonne University – Pitié Salpêtrière Hospital)
