Team 4 – SLIM Team: Cellular and Systemic Lipid Metabolism in Cardiometabolic DiseasesAXIS 1. Alteration of cellular and tissue lipid homeostasis in cardiometabolic diseases (Wilfried Le Goff & Isabelle Guillas)The objective of this research axis is to identify the mechanisms responsible for the alteration of lipid homeostasis in the liver, adipose tissue, intestine, heart and at the level of the vascular wall and to study their contribution to the inflammation and remodeling of these tissues during cardiometabolic diseases.AXIS 2. Study of the close link between the alteration of systemic lipid metabolism and the inflammatory component in human pathophysiology (Wilfried Le Goff)The objective of this research axis is to identify new physiopathological pathways linking circulating lipid metabolism and inflammation in common or rare pathologies associated with dyslipidemia and chronic inflammation resulting or not from genetic mutations.AXIS 3. Identification of new biomarkers of cardiovascular mortality (Maryse Guérin)The objective of this research axis is to study the mechanisms through which the alteration of cholesterol efflux from macrophages is associated with low-grade inflammation and cardiovascular diseases.AXIS 4. Postprandial state and metabolism of lipoproteins rich in triglycerides (Maryse Guérin)AXIS 5. Revisiting the role of high-density lipoproteins in cardiovascular disease (Anatol Kontush)AXIS 5. Revisiting the role of high-density lipoproteins in cardiovascular disease (Anatol Kontush)The objective of this research axis is to assess the impact of the role of high density lipoproteins in the reverse transport of cholesterol residues to the liver in the development of cardiovascular diseases.The objectives of our research
- Elucidate the mechanisms involved in the alteration of cellular and systemic lipid metabolism in cardiometabolic diseases.
- Study the relationship between the structure and function of lipoproteins
- Propose new therapeutic approaches in cardiometabolic diseases
- Identify and validate new biomarkers of cardiovascular risk
Major Publications14/10/2021Profound systemic alteration of the immune phenotype and an immunoglobulin switch in Erdheim-Chester disease in a single-center of 78 patients13/10/2020Interleukin-1β and Risk of Premature Death in Patients With Myocardial Infarction26/12/2020HDL and Reverse Remnant-Cholesterol Transport (RRT): Relevance to Cardiovascular Disease27/10/2020Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease02/01/2020A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke08/08/2019Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome25/12/2018Association of Serum Cholesterol Efflux Capacity With Mortality in Patients With ST-Segment Elevation Myocardial Infarction07/08/2018Clinical Genetic Testing for Familial Hypercholesterolemia: JACC Scientific Expert Panel03/08/2018Hypoalphalipoproteinemia and BRAF V600E Mutation Are Major Predictors of Aortic Infiltration in the Erdheim-Chester Disease11/03/2016Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease27/03/2015HDL particle size is a critical determinant of ABCA1-mediated macrophage cellular cholesterol export23/09/2014Adipocyte ATP-binding cassette G1 promotes triglyceride storage, fat mass growth, and human obesityMembers of the teamWilfried LE GOFF(CR, INSERM) – HDRMaryse GUERIN(DR-INSERM) – HDRAnatol KONTUSH(DR, INSERM) – HDRIsabelle GUILLAS(MCU, Sorbonne University)Martine GLORIAN(MCU, Sorbonne University)Alain CARRIE(PU-PH, AP-HP) – HDRJean-Marc LACORTE(PU-PH, AP-HP) – HDREric BRUCKERT(PU-PH, AP-HP) – HDRMaryam DARABI(Postdoc, Sorbonne University)Veronica DAHIK(PhD student, Sorbonne University)Alexandre MOTTE(PhD student, Sorbonne University)Malik TARADEH(PhD student, Sorbonne University)Cinnamon REYDELLET(PhD student, Sorbonne University)Clement Materne(PhD student, Sorbonne University)Eric Frisdal(IR, INSERM)Olivier Bluteau(IR, AP-HP)Hervé DURAND(IE, INSERM,)Sophie GALIER(TR, INSERM)Randa BITTAR(PH, AP-HP)
