Department of Intensive Medicine and ResuscitationThe Intensive Resuscitation Medicine department is affiliated with the research unit on cardiovascular and metabolic diseases UMRS 1166-ICAN of the Sorbonne University Faculty of Medicine. The service treats patients for the most severe forms of cardiogenic shock and acute respiratory distress syndrome, in particular those requiring the establishment of extracorporeal circulation by ECMO (Extracorporeal Membrane Oxygenation).
The main research activities are related to the following areas: circulatory assistance in collaboration with the cardiac surgery department, acute respiratory distress syndrome, protective ventilation, pneumonia acquired under mechanical ventilation, cardiac arrest, myocarditis, induced hemostasis disorders by ECMO.Key figuresThe Intensive Medicine Resuscitation department takes care of around 1,300 patients per year, including 650 to 750 patients in the “resuscitation” section. Nearly half of these intensive care patients require circulatory or respiratory assistance by ECMO (Extracorporeal Membrane Oxygenation).
A large proportion of these patients are admitted after the Mobile Circulatory Support Unit of the cardiac surgery department moved to an intensive care unit in Ile-de-France to implant ECMO. The cardiology institute thus serves as an ECMO reference center for Ile-de-France.The main pathologies for which patients are referred to our department are:
- Cardiogenic shock complicating myocardial infarction, dilated cardiomyopathy, fulminant myocarditis…
- Heart transplant
- Acute respiratory distress syndrome from any cause (bacterial pneumonia, influenza, COVID-19)
- Infectious endocarditis
Service objectivesThe Intensive Medicine Resuscitation service works, whether for the clinical part or for the research part, in close collaboration with the cardiology department and the cardiac surgery service with the aim of maintaining clinical expertise in the fields of cardiogenic shock and of the SDRA and to pursue research projects in these fields.Current projectsThe main clinical research projects already underway are:
- ANCHOR: randomized study to assess the benefit of veno-arterial ECMO in myocardial infarction complicated by cardiogenic shock
- LEVOECMO: randomized study to assess the interest of Levosimendan for ECMO serfdom
- PRONECMO: randomized study to assess the benefit of prone decubitus in patients with severe ARDS on veno-venous ECMO
- Other projects in the fields of antibiotic therapy, capillary leakage, hemostasis will begin soon
Major Publications02/2021Long-Term Disabilities of Survivors of Out-of-Hospital Cardiac Arrest: The Hanox Study08/11/2020Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome associated with COVID-19: a retrospective cohort study22/08/2020Venoarterial extracorporeal membrane oxygenation to rescue sepsis-induced cardiogenic shock: a retrospective, multicentre, international cohort study03/02/2020Prone positioning monitored by electrical impedance tomography in patients with severe acute respiratory distress syndrome on veno-venous ECMO09/06/2020Microcirculation Evolution in Patients on Venoarterial Extracorporeal Membrane Oxygenation for Refractory Cardiogenic Shock09/06/202011/2019Ultra-Protective Ventilation Reduces Biotrauma in Patients on Venovenous Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome15/10/2019Mechanical Ventilation Management during Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome. An International Multicenter Prospective Cohort05/2019Feasibility and safety of extracorporeal CO 2 removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study05/2019Use of non-carbapenem antibiotics to treat severe extended-spectrum β-lactamase-producing Enterobacteriaceae infections in intensive care unit patients26/12/2017Extracorporeal Membrane Oxygenation (ECMO) for Lung Injury in Severe Acute Respiratory Distress Syndrome (ARDS): Review of the LiteratureMembers of the teamProfessor Alain CombesHead of Service, PUPHProfessor Charles-Edouard LuytPUPHProfessor Matthew SchmidtPUPHDr Nicolas BrechotpHDr Guillaume HekimianpHDr. Marc Pineton de ChambrunClinic directorDr Juliette ChommelouxClinic directorDr Lucie LefevreContract Hospital PractitionerDr Petra BarhoumSpecialist assistantDr. Antoine TrogerSpecialist AssistantFind out more
